Lu Zhou Selected Research

Phosphoglycerate Mutase (Phosphoglyceromutase)

1/2021	A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer.
1/2021	HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.
1/2021	Design, synthesis, and biological evaluation of 1,3,6,7-tetrahydroxyxanthone derivatives as phosphoglycerate mutase 1 inhibitors.
12/2019	A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer.
11/2019	An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma.
4/2019	Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment.
2/2019	Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors.
1/2018	The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors.
1/2018	Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation.
12/2017	Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1.

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Lu Zhou Research Topics

Disease

55	Neoplasms (Cancer) 06/2022 - 04/2007
12	Inflammation (Inflammations) 12/2021 - 04/2014
12	Neoplasm Metastasis (Metastasis) 01/2021 - 09/2013
9	Hypoxia (Hypoxemia) 09/2021 - 01/2015
9	Carcinogenesis 01/2021 - 02/2010
7	Infections 01/2020 - 10/2006
6	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2020
6	Chronic Obstructive Pulmonary Disease (COPD) 05/2021 - 01/2020
5	Necrosis 01/2022 - 01/2014
5	Osteosarcoma (Osteogenic Sarcoma) 01/2021 - 09/2011
5	Atherosclerosis 02/2019 - 02/2014
5	Neurofibromatosis 2 (Neurofibromatosis Type II) 01/2017 - 08/2011
5	Neurilemmoma (Schwannoma) 01/2015 - 02/2010
4	Carcinoma (Carcinomatosis) 06/2022 - 04/2015
4	Hepatocellular Carcinoma (Hepatoma) 06/2022 - 06/2016
4	Stomach Neoplasms (Stomach Cancer) 11/2021 - 11/2019
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 05/2016
4	Disease Progression 01/2021 - 10/2016
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2021 - 01/2016
4	Wounds and Injuries (Trauma) 12/2020 - 01/2014
4	Breast Neoplasms (Breast Cancer) 10/2020 - 01/2015
4	Body Weight (Weight, Body) 06/2018 - 06/2012
4	Insulin Resistance 01/2018 - 02/2014
4	Pancreatic Neoplasms (Pancreatic Cancer) 03/2013 - 08/2005
3	Non-alcoholic Fatty Liver Disease 09/2022 - 09/2019
3	Osteoporosis 05/2022 - 01/2020
3	Melanoma (Melanoma, Malignant) 01/2022 - 01/2015
3	Fibrosis (Cirrhosis) 01/2022 - 06/2015
3	Colonic Neoplasms (Colon Cancer) 01/2021 - 03/2013
3	Leukemia 01/2021 - 08/2014
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 11/2012
3	Squamous Cell Carcinoma of Head and Neck 01/2021 - 01/2019
3	Infarction (Infarctions) 01/2020 - 06/2015
3	Precocious Puberty 01/2020 - 01/2019
3	Ulcerative Colitis 12/2019 - 12/2008
3	Autoimmune Hepatitis 01/2019 - 12/2017
3	Pre-Eclampsia (Preeclampsia) 01/2019 - 09/2016
3	Meningioma (Meningiomas) 01/2016 - 11/2012
2	Glioma (Gliomas) 09/2022 - 05/2015
2	Triple Negative Breast Neoplasms 06/2022 - 01/2021
2	Endometriosis 02/2022 - 07/2014
2	Infertility (Sterility) 01/2022 - 07/2014
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 01/2021
2	Hepatitis 01/2022 - 12/2017
2	Brain Neoplasms (Brain Tumor) 01/2022 - 01/2021
2	COVID-19 01/2022 - 01/2022
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 01/2019
2	Bites and Stings (Sting) 12/2021 - 01/2021
2	Autoimmune Diseases (Autoimmune Disease) 12/2021 - 01/2021
2	Thrombotic Thrombocytopenic Purpura 12/2021 - 01/2020

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 09/2022 - 04/2007
16	EnzymesIBA 01/2022 - 11/2011
16	Pharmaceutical PreparationsIBA 01/2022 - 01/2006
12	Phosphoglycerate Mutase (Phosphoglyceromutase)IBA 01/2021 - 11/2012
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2007
8	Neurofibromin 2 (Merlin)IBA 01/2017 - 02/2010
6	CytokinesIBA 01/2022 - 06/2015
6	phosphatidylcholine-ceramide phosphocholine transferaseIBA 01/2022 - 09/2015
6	Phosphotransferases (Kinase)IBA 01/2022 - 03/2013
5	LipidsIBA 09/2022 - 03/2015
5	LipopolysaccharidesIBA 06/2022 - 01/2015
5	Interleukin-6 (Interleukin 6)IBA 09/2021 - 06/2018
5	SmokeIBA 01/2021 - 01/2020
5	Hormones (Hormone)IBA 10/2020 - 11/2015
4	Glucose (Dextrose)FDA LinkGeneric 06/2022 - 11/2015
4	GoldIBA 03/2022 - 10/2019
4	CateninsIBA 01/2022 - 12/2011
4	Long Noncoding RNAIBA 01/2022 - 01/2018
4	Interleukin-17 (Interleukin 17)IBA 01/2021 - 01/2019
4	Biological ProductsIBA 01/2021 - 06/2016
4	MicroRNAs (MicroRNA)IBA 01/2021 - 08/2014
4	3-phosphoglycerate (glycerate 3-phosphate)IBA 04/2019 - 11/2012
4	2-phosphoglycerate (glycerate 2-phosphate)IBA 04/2019 - 11/2012
3	Circular RNAIBA 09/2022 - 01/2019
3	RNA (Ribonucleic Acid)IBA 04/2022 - 11/2015
3	IronIBA 01/2022 - 10/2006
3	Concanavalin AIBA 01/2022 - 12/2017
3	Angiotensin IIIBA 01/2022 - 01/2015
3	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2018
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 08/2015
3	Liposomes (Liposome)IBA 01/2021 - 09/2015
3	CholesterolIBA 01/2021 - 11/2015
3	Amyloid (Amyloid Fibrils)IBA 01/2021 - 01/2020
3	AGRO 100IBA 12/2020 - 09/2015
3	Docetaxel (Taxotere)FDA Link 05/2020 - 05/2016
3	Matrix Metalloproteinases (MMPs)IBA 01/2020 - 09/2013
3	Transcription Factors (Transcription Factor)IBA 12/2019 - 01/2015
3	Serine (L-Serine)FDA Link 04/2019 - 12/2011
3	Small Interfering RNA (siRNA)IBA 01/2019 - 11/2012
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017 - 02/2010
3	LeptinIBA 01/2016 - 10/2013
2	Messenger RNA (mRNA)IBA 01/2022 - 01/2021
2	AntibodiesIBA 01/2022 - 12/2021
2	SteroidsIBA 01/2022 - 12/2016
2	Mitochondrial DNA (mtDNA)IBA 12/2021 - 01/2021
2	thiamine triphosphorate (TTP)IBA 12/2021 - 01/2020

Therapy/Procedure

23	Therapeutics 03/2022 - 04/2008
4	Radiotherapy 01/2022 - 01/2012
4	Drug Therapy (Chemotherapy) 01/2022 - 01/2019
2	Cesarean Section (Caesarean Section) 04/2022 - 12/2021